The old village lies within fortifications which date back to the 11th and 12th Centuries. There have also been artifacts found that date back to Roman times.

Built on a hill, it is close to Mont Ventoux, at the foot of the Dentelles de Montmirail, like Sablet it is at the centre of the tourist triangle formed by Carpentras, Orange and Vaison-la-Romaine. The village is built  around its church of St Barthélemy.  Its narrow winding streets lead to fortified walls surrounding the Medieval Vassadel castle,  and to the church with its elegant Provençal-style steeple  stretching upwards from the top of a watchtower dating back to the 12th century.

Well known for its outstanding wines which carry the designation of Cote du Rhone wines as well as its own Vacqueyras appellation.

Vacqueyras is still essentially an agricultural community, and produces one of the three major vintages of Cotes du Rhone de Vaucluse. The vineyards extend as far as the Dentelles de Montmirail. The Vacqueyras vineyards have been renowned for many years, but it was only in 1990 that the local wine-growers obtained official recognition of the quality of their wines, which have now become a Côtes du Rhône Appellation d’Origine Controlee (AOC).